Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity

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Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity

The Drosophila anterior-posterior axis is specified when the posterior follicle cells signal to polarise the oocyte, leading to the anterior/lateral localisation of the Par-6/aPKC complex and the posterior recruitment of Par-1, which induces a microtubule reorganisation that localises bicoid and oskar mRNAs. Here we show that oocyte polarity requires Slmb, the substrate specificity subunit of t...

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Dev109827 2984..2992

The Drosophila anterior-posterior axis is specified when the posterior follicle cells signal to polarise the oocyte, leading to the anterior/lateral localisation of the Par-6/aPKC complex and the posterior recruitment of Par-1, which induces a microtubule reorganisation that localises bicoid and oskarmRNAs. Here we show that oocyte polarity requires Slmb, the substrate specificity subunit of th...

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ژورنال

عنوان ژورنال: Development

سال: 2014

ISSN: 1477-9129,0950-1991

DOI: 10.1242/dev.109827